This document contains the TiNMAN exploratory questions used to help identify the existance of adenomyosis and/or endometriosis and common co-occuring conditions including

It also includes questions covering the menstrual cycle, overlapping symptoms and various aspects of psychological and holistic wellbeing.

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A cyclical period is a monthly sequence of hormonal, ovarian, and uterine changes designed to prepare the body for potential pregnancy. The length of this menstrual cycle can vary between individuals but is typically between every twenty one to thirty five days, with around twenty eight days being the average, and it tends to become more regular with age.

The menstrual cycle consists of four distinct phases and, using a textbook model twenty eight day cycle as a broad guide, they are
  • menstruation, commonly referred to as the period, from days one to five and a time of bleeding, cramps and low energy. This is when, if pregnancy did not occur in the previous cycle, progesterone and estrogen levels drop and trigger the uterus to shed its lining.
  • follicular, from days six to fourteen and a time of rising energy and increased motivation. This is when the pituitary gland releases follicle-stimulating hormone so causing follicles in the ovaries that are filled with fluid and contain the eggs to mature. The dominant follicle produces estrogen, causing the uterine lining to thicken and the body prepares to release an egg.
  • ovulation, typically around day fourteen and lasting about twenty four hours, typified by peaking energy, high libido and increased confidence. This is when a surge in luteinizing hormone, triggered by high estrogen levels, prompts the ovary to release the matured egg and the fertile window opens
  • luteal, from days fifteen to twenty eight and a time of potentially life-affecting behavioural, emotional, and physical changes. This is the time when the ruptured follicle, known as the corpus luteum, produces progesterone to maintain the uterine lining for a potential fertilised egg. If no pregnancy occurs, the corpus luteum shrinks so prompting the menstrual cycle to restart.
While occasional irregularities within a usually regular menstrual cycle are natural, consistent and significant deviations from a “normal” pattern can indicate underlying issues, with particular emphasis here on
  • Polymenorrhea, typified by periods that occur too frequently, with less than twenty one days between them
  • Oligomenorrhea, infrequent periods that occur more than thirty five days apart and often result in only six to eight periods per year
  • Amenorrhea, when a period is absent and does not occur for ninety days or more.
Based on your last three menstrual cycles, how would you describe the amount of time you expect between your previous and current or next period?


This question explores premenstrual syndrome, often referred to as PMS. It is characterised by a combination of unpleasant but mostly manageable behavioural, emotional, and physical changes that occur in the luteal phase of the normal menstrual cycle, beginning up to two weeks before the period starts, and that cease shortly after the onset of menstruation.

Common behavioural and emotional symptoms, which under normal circumstances would be fully absent for least one week in the menstrual cycle, includeCommon physical symptoms includeIf this time included the two weeks leading up to your current or next expected period then, on those days, how would you describe the impact of any unpleasant but mostly manageable behavioural, emotional, and physical changes linked to your menstrual cycle?


This question explores symptoms of premenstrual dysphoric disorder, often referred to as PMDD and a far more severe variant of premenstrual syndrome. PMDD is responsible for intense and potentially overwhelming psychological distress that significantly interfers with daily life, in particular with relationships, work or education, and social life.

In addition to any physical symptoms also associated with PMS, key indicators of PMDD that occur during the second half of the menstrual cycle, and sometimes in the first few days of menstruation, includeA woman suffering from premenstrual dysphoric disorder may become increasingly drawn toPMDD is classified as a mental illness and for it to be considered a possibility your symptoms MUSTIf this time included the two weeks leading up to your current or next expected period then, on those days, how would you describe the impact of any severe and life-affecting behavioural or emotional changes linked to your menstrual cycle?


Menstrual tension headaches are typically only mildly or moderately painful but can last from at least thirty minutes up to several days. They feel like a pressure band around the head and are typically not made worse by physical activity.

Menstrual migraines, generally more severe and longer-lasting than other migraine headaches, typically occur two days before the start of bleeding until three days after.

Symptoms of menstrual migraines includeIf this time included days closely leading up to or taking place during your period then, on those days, how much were you affected by headaches tied to your menstrual cycle?

Endometrial tissue is the mucous membrane that lines the uterus. It is essential for both menstruation and pregnancy and should thicken and shed monthly under hormonal influence.

Severe period pain, known as dysmenorrhea, can be life-affecting and, if chronic, can lead to long-term changes in how the body processes pain.

Period pain that is not linked to an underlying medical condition is known medically as primary dysmenorrhoea. It is caused by the womb contracting to shed its inner lining during a period and usually starts just before the period and can last up to seventy-two hours.

Common markers includeSecondary dysmenorrhoea is caused by an underlying medical condition, with period pain that may begin earlier in the menstrual cycle, a few days before the period, and lasts longer throughout the period than primary dysmenorrhea. It can be associated withIf this time included days closely leading up to or taking place during your period then, on those days, how much were you affected by period pain?

A typical period involves the loss of the equivalent of about one to five tablespoons of blood over two to seven days, with heaviest flow of brighter red blood in the first two days, often followed by a lighter flow of brown or pink spotting.

Heavy periods, known medically as menorrhagia, can be associated with endometriosis, adenomyosis, pelvic inflammatory disease, and uterine fibroids, and symptoms can includeExcessive bleeding, often lasting more than seven days, can cause period-related iron-deficiency anaemia. The significant blood loss depletes iron stores that are essential for the production of haemoglobin, the protein required for the creation of oxygen-carrying red blood cells, and this type of anaemia can lead toIf this time included your period then how would you describe your menstrual flow?

Irritable bowel syndrome, often referred to as IBS, is a chronic functional disorder caused by the gut and brain over-communicating and affecting the digestive system.

IBS often coexists with increased anxiety. The body's stress response to anxiety is to activate a “fight-or-flight” reaction and release adrenaline and cortisol, the body's primary stress hormones. A consequence is the curbing of non-essential functions including digestion and the potential triggering of immediate abdominal pain, bloating, and bouts of constipation, diarrhoea or both.

IBS can be categorised asThis question focuses on pain or discomfort you may have experienced as a result of symptoms of irritable bowel syndromepelvic floor dysfunction, in particularTo what extent have you experienced symptoms associated with irritable bowel syndrome?

Pelvic floor dysfunction is an umbrella term for conditions including pelvic organ prolapse, urinary incontinence and anal incontinence. It describes an inability to properly control, relax, or coordinate pelvic floor muscles and is caused by weakened or injured muscles. Very common in the adult female population, it is typically triggered by childbirth, aging, or surgery.

This question focuses on pain or discomfort you may have experienced as a result of symptoms of pelvic floor dysfunction, in particularTo what extent have you experienced symptoms associated with pelvic floor dysfunction?

Pelvic inflammatory disease is a bacterial infection of the upper female reproductive system - the uterus, fallopian tubes and ovaries - and can affect any woman with a womb, although not everyone with the disease will have symptoms. It often stems from untreated sexually transmitted diseases such as chlamydia and gonorrhea.

This question focuses on pain or discomfort you may have experienced as a result of symptoms of pelvic inflammatory disease, in particularTo what extent have you experienced symptoms associated with pelvic inflammatory disease?

Polycystic ovary syndrome is a common hormonal disorder affecting reproductive-aged women. A major factor is high insulin levels, which boosts production of androgens which are the steroid hormones responsible for developing and maintaining masculine characteristics and include testosterone, the primary male sex hormone.

This question focuses on pain or discomfort you may have experienced as a result of symptoms of polycystic ovary syndrome, in particularTo what extent have you experienced symptoms associated with polycystic ovary syndrome?

Uterine fibroids, known medically as leiomyomas, are solid non-cancerous hormone-driven muscular tumors that grow in or on the uterus, often during reproductive years and mainly affect women who have not been through the menopause. Not everyone has symptoms.

This question focuses on pain or discomfort you may have experienced as a result of symptoms of uterine fibroids, in particularUterine fibroids increase the surface area of the uterine lining, which means there is more tissue to shed during the period. They can also prevent the uterus from contracting efficiently to control blood flow and develop a dense vascular capsule, a peripheral network of blood vessels to facilitate their growth. This can often increase overall lower resistance uterine blood flow, and symptoms during menstruation can includeTo what extent have you experienced symptoms associated with uterine fibroids?

Symptoms on the bladder for adenomyosis, irritable bowel syndrome, pelvic floor dysfunction and uterine fibroids can be persistant.

Symptoms on the bladder from endometriosis tend to occur in a regular pattern, usually worsening in the days leading up to and during a period.

Common symptoms of problems with the bladder includeCyclical symptoms can also includeBladder pain syndrome, a chronic condition that is also known as interstitial cystitis, causes pain in the lower abdomen or pelvic region and discomfort that worsens as the bladder fills and eases after urination, accompanied by a frequent and urgent need to urinate.

How much were you affected by problems associated with your bladder?

Symptoms on the bowel for adenomyosis, irritable bowel syndrome and pelvic floor dysfunction can be persistant

Symptoms on the bowel from endometriosis tend to occur in a regular pattern, usually worsening in the days leading up to and during a period.

Dyschezia is the medical term for chronic bowel problems and symptoms includeCyclical dyschezia, associated with endometriosis on the bowel, often affects the lower part of the intestines where endometrial-like tissue can be superficial or deep infiltrating and symptoms can includeHow much were you affected by problems associated with your bowels?

Dyspareunia is the medical term for pain experienced during sexual intercourse.

Deep dyspareunia goes beyond superficial pain and describes a pain or discomfort that a woman might experience deep internally within pelvic area during or after sexual intercourse, often triggered by deep thrusting. It can be linked to adenomyosis, endometriosis, irritable bowel syndrome, pelvic inflammatory disease, and uterine fibroids.

How would you describe your experiences of deep internal pain or discomfort within your pelvic area during or after sexual intercourse?

For most women aged thirty-five or under, having regular unprotected sex every two to three days results in pregnancy within one year. After the age of thirty-five fertility declines naturally due to reduced egg quality and quantity.

Within the context of endometriosis and certain other conditions that it can share symptoms with, reasons for difficulty conceiving may includeIf you are trying to conceive then how would you describe your current status?

A “frozen pelvis” is a severe and often debilitating condition where pelvic organs including the uterus, ovaries, bladder, and bowel lose mobility and become densely adhered to each other when extensive scarring acts like glue.

Causes of a frozen pelvis can include advanced endometriosis, contributing adenomyosis and pelvic inflammatory disease. Symptoms tend to build over a considerable period of time and includeHow much were you affacted by constant feelings of pain and having a constant and solid immoveable mass in your pelvis?

Endometriosis is a chronic gynecological condition where patches of endometrial-like tissue grow outside the uterus, typically appearing on the pelvic lining, ovaries, uterosacral ligaments, bladder and bowel.

Not everyone experiences symptoms in the same way but they will commonly peak in the days before and during a period when hormonal changes cause inflammation of misplaced endometrial-like tissue.

The peritoneum is a thin and smooth continuous membrane that lines the abdominal and pelvic walls and covers most of the abdominal organs. It serves to provide structural support and reduce friction between organs through lubrication, provide pathways for blood vessels and nerves, and act as a barrier to defend against infection.

Symptoms of peritoneal endometriosis can includeTo what extent have you experienced symptoms associated with peritoneal endometriosis?

Deep infiltrating endometriosis affects structures in the pelvic and abdominal region such as the bowel, bladder, nerves and blood vessels. It is more likely to cause significant symptoms usually associated with the structure it is buried into and commonly peaks around the time of a period.

Symptoms of deep endometriosis can includeDiseased tissue can grow on or near peripheral pelvic nerves and the lesions can directly attack nerves or create scar tissue, known as fibrosis, that pulls and traps the nerves. The release of inflammatory chemicals such as cytokines and prostaglandins can cause further pain increases and affected nerves includeTo what extent have you experienced symptoms associated with deep endometriosis?

Extra-pelvic endometriosis affects structures outside of or distant from the pelvic and abdominal region and symptoms commonly peak around the time of a period.

Catamenial epilepsy occurs when seizures are triggered by endometriosis-including brain lesions during menstruation.

Pain in the shoulder-tip can occur if a patch of diseased tissue develops under the diaphragm, stimulating the phrenic nerve, a critical motor and sensory nerve in the neck that is responsible for driving respiration by providing exclusive motor control to the diaphragm.

Tissue damage can extend beyond the pelvis and affect the diaphragm, chest, and abdominal wall, especially after surgeries like C-sections, leading to possible pain or bleeding during menstruation from old surgical scars, or in areas such as the chest so causing shortness of breath or a cough which may bring up blood.

To what extent have you experienced symptoms associated with extra-pelvic endometriosis?

The amount of endometrial-like tissue does not always correspond to the level of pain a woman experiences. A small amount can be agonising in one case whilst a large amount can go unnoticed in another.

An endometriosis “belly” describes a pronounced bulge in the lower abdomen that can appear suddenly, last for hours or days, and typically resembles a pregnancy bump but that is not caused by soft fat-based abdominal weight and is not linked to pregnancy.

This severe and often painful visible swelling of the abdomen beyond its normal girth is cyclical, frequently occuring during menstruation or ovulation and subsiding after.

How much were you affected by painful abdominal swelling that appeared suddenly and always seemed to worsen around the time of your period?

Adenomyosis is a chronic gynecological condition where patches of endometrial-like tissue grow into the muscular uterine wall rather than lining it. This leads to a thickened uterus and these patches, also known as implants, respond to hormonal changes and cause severe bleeding during menstruation.

The core symptoms of adenomyosis are those that are less associated with other conditions and includeTo what extent have you experienced core symptoms of adenomyosis?

Adenomyosis can trigger severe, labour-like uterine contractions that are often more frequent, intense, and uncoordinated than would typically be expected.

Symptoms of uterine contractions associated with adenomyosis includeTo what extent have you experienced uterine contractions that are not related to pregnancy and fit a pattern associated with adenomyosis?

An adenomyosis “belly” describes a pronounced bulge in the lower abdomen that typically resembles a small pregnancy bump of three to six months but that is not caused by soft fat-based abdominal weight and is not linked to pregnancy. Unlike cyclical bloating, this swelling does not go away after a period.

Symptoms of an adenomyosis belly can includeIf your body matches the symptoms of an adenomyosis belly then how would you describe its appearance?

Empathy describes the ability to relate to another person on a deeper emotional level and it forms a vital part of social connectedness.

Cognitive empathy requires intellect and a conscious effort to try to understand another person's emotions and guess reasonably accurately what they are thinking or feeling and, importantly, why.

Emotional empathy describes the ability to share another person's emotional experience and is sometimes described as “feeling what they feel”. It is typically founded on the person's individual experiences of similar emotions or situations, and examples includeHow often have you been upset by a lack of empathy from family or friends for the distress you experienced as a direct result of your pain and discomfort?

Medical gaslighting, also known as illness invalidation or symptom invalidation, occurs when healthcare professionals habitually dismiss, invalidate, or trivialise a patient's symptoms. In some cases it can lead to a patient doubting their own experiences or questioning their sanity.

Common indicators of medical gaslighting includeThe feelings of defeat and helpnessness linked to the accumulated psychological harm of medical dismissal can lead to a patient becoming help-averse or losing trust in the medical establishment.

Learned helplessness describes a mindset whereby a person internalises a feeling of helplessness and hopelessness when they repeatedly encounter anxiety-provoking situations that they are unable to overcome. They then start to believe that they cannot control or change things so stop trying, even if opportunities to gain control or break the negative cycle become available. Learned helplessness can lead to a significantly lower level of general functioning than a person might otherwise be capable of.

How would you describe the impact on your overall daily functioning and wellbeing of what could reasonably be described as “medical gaslighting”?

The word “resilience” is used here to describe the ability to adapt positively to the significant stressors associated with chronic disease.

The expression “silent suffering” is used here to describe the act of hiding the persistant physical and psychological distress associated with adenomyosis and endometriosis despite a reducing resilience.

Examples include“The self” refers to an individual's concept of identity. It develops over time and is shaped by personal experiences, social interactions, and internal thought processes.

Silent suffering can lead toHow would you describe the impact on your overall daily functioning and wellbeing of what could reasonably be described as “suffering in silence”?

The expression “emotional dysregulation” is used here in relation to adenomyosis and endometriosis to specifically describe difficulty managing and controlling intense feelings and emotional responses that are driven in particular by chronic pain, high estrogen levels, and trauma and accumulated psychological harm from delayed diagnosis.

Internalised emotional dysregulation can manifest as behaviours such as social withdrawal, anxiety, or depression, where the distress is directed inward and may not be seem outwardly obvious and symptoms can include“Endo rage”, a visible form of externalised emotional dysregulation, which often peaks during the menstrual cycle or during flare-ups, the sudden intensification of symptoms such as severe pelvic pain, fatigue, and digestive issues that can last from hours to weeks, leading toDysregulated emotions can become increasingly crippling and can lead to struggles within the home environment and developmental delays, including substandard work or academic performance and attendance.

How great would you describe the psychological damage of living with with chronic disease on your ability to manage and control your feelings and emotional responses?

The expression “profound overfatigue” is used here to describe a beyond-mild to severe form of physical exhaustion that does not result from simple tiredness and that often worsens from mid-cycle to pre-menstrual, often peaking before, during, or shortly after menstruation, or during ovulation.

Descriptions of profound overfatigue include “bone-deep” and “crushing” or feeling “drained”, “drugged”, “paralysed”, “shattered”, or “tranquilised”.

When the immune system attempts to combat diseased tissue cytokines, also known as inflammatory toxins, are secreted by the tissue and it is these internal chemicals that lead to the feeling of extreme fatigue.

Key markers includeIn terms of its impact on your physical health and disruption to day-to-day activities and events that provide a positive life balance, how would you describe the severity of profound and uncontrollable overfatigue?

Psychological injury linked to living with chronic pain can lead to a deep, persistent state of low physical and mental energy in response to the body's psychological and physiological resources being overworked for an extended period of time.

Left to continue uninterrupted this level of fatigue can lead to burnout, a state of physical, mental, and emotional exhaustion following an extended episode of severe stress and physiological disruption and markers includeAn overwhelm “hangover” refers to the lingering psychological and physical effects on the body's mental and physical resources and symptoms includeHow would you describe the amount of physical and emotional energy you are able to muster to tackle your everyday with interest, motivation and confidence?

This fibromyalgia question specifically explores female symptoms that are either mind or mood affecting or physiologically or anatomically broad.

Fibromyalgia is a chronic disorder related to a change in the way the central nervous system - the brain, spinal cord and nerves - process pain messages carried around the body.

Broad symptoms for fibromyalgia can vary between individuals and are changeable, unexpectedly improving or worsening, but common ones includeTo what extent have you been affected by broad symptoms of fibromyalgia?

This fibromyalgia question specifically explores female symptoms that occur within the middle-body, the part that includes only the chest, abdomen, back and pelvis.

Symptoms can includeTo what extent have you been affected by symptoms of fibromyalgia that were centred within your middle-body?

The circadian rhythm controls the cycles your internal body clock repeats about every twenty four hours that tell you when it is time to sleep or wake. Disruption of the circadian rhythm can both worsen and be worsened by inflammation, pain, and hormonal imbalance linked to endometriosis.

Your body tries to synchronise your sleep-wake cycle to cues from the environment, such as seasonally adjusting to when it gets light or dark outside, when you eat, and when you are physically active.

Misalignment canRate the disruption to your sleep cycle of a misaligned or interrupted body clock?

Sleep is a critical component of mental and physical health and disruption can lead to a worsening state of mental and physical wellbeing.

Insomnia can surface throughCommon symptoms includeHow would you describe the impact of disrupted sleep and any resulting tiredness on your daily functioning and emotional stability?

The expression “emotional stability” is used here to define the ability to maintain a calm and balanced emotional state and manage stress and challenges without extreme reactions or mood swings.

Anxiety is the internal emotional and physical state that involves persistent worry and a prolonged, internal feeling of apprehension or dread concerning imminent or imagined future events and can exist without a clear cause.

Symptoms of anxiety can includeSomatic relates to the body and physiological refers to its normal functions, processes, and mechanisms. Somatic anxiety describes the physiological response to cognitive anxiety and symptoms can be single, multiple or varying and range from mild to severe, and can includeHow would you describe the impact of mental anxiety and any consequent anxiety-driven physical stress on your daily functioning and emotional stability?

Being depressed is the normal but temporary feeling of sadness in response to occasional misery or when something goes wrong. It lasts for no more than a few hours or days before a return to relative normality.

Depression is a persistent and severe condition whereby a person suffers from a heavy mental state of sadness and low mood which continues without any meaningful respite for weeks or more and significantly interferes with all aspects of daily life.

Symptoms can includeAlongside the severe pain associated with adenomyosis and endometriosis, the increasing sense of isolation, often resulting from dismissive medical attitudes, intolerably long delays in diagnosis and a seemingly lack of effective treatments, can lead to progessively darker thoughts about the value of the future and possibly lead to suicidal ideation.

To what extent were you affected by a state of low mood, lack of motivation and loss of interest in even the most basic activities?

Quality of life is a multidimensional and personally-subjective concept but the chronic pain, fertility challenges, extreme fatigue and sense of isolation associated with adenomyosis and endometriosis can have a profound negative impact.

Areas of interest that might help inform how you feel includeHow would you describe your overall quality of life?

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